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The news: Eli Lilly joined forces with direct-to-consumer (D2C) telehealth company Ro to offer single-dose vials of its GLP-1 Zepbound to Ro patients with obesity. Previously, this reduced price form of the medication was only available on the drugmaker鈥檚 D2C website for its LillyDirect self-pay pharmacy (meaning insurance isn鈥檛 accepted).

As the costs of doing business increase, direct-to-consumer (D2C) brands are struggling to find and keep customers. Some brands are selling their products through Amazon to capitalize on its search power. Others are turning to brick-and-mortar stores to help out.

The next phase of direct-to-consumer (D2C) retail won鈥檛 be defined by a singular distribution strategy, but rather by the goal of making a real connection with customers. To get to the next level, D2Cs must use their physical presence, partnerships, marketing dollars, and customer data.

The ecommerce giant also launched a low-cost line of essential grocery items, Amazon Saver, in late 2024, with extra discounts for Prime members. The strongest private label retailers draw shoppers to their own brands. Limited-selection retailers (such as warehouse clubs and discount grocers) lean into private label to offer value-focused products and drive customer loyalty to their brands.

Gopuff looks to diversify its revenue streams: The company launched a platform to allow brands to fulfill ecommerce orders on their own websites.

As Facebook loses relevance with younger audiences, D2C ad budgets for CPG brands are diversifying into emerging channels.

Digitally native vertical brands (DNVBs) have a long way to go to catch up to established brands. While established brands will make up $134.55 billion in D2C ecommerce sales in 2023, digitally native brands will make up just $34.84 billion, according to our March 2023 forecast.

The news: Amazon鈥檚 direct-to-consumer (D2C) telehealth business expanded its services to include upfront, fixed pricing for the treatment of five conditions鈥攕kin care, hair loss, erectile dysfunction (ED), eyelash growth, and motion sickness. Why it matters: The new offering places Amazon One Medical Pay-per-visit in direct competition with D2C healthcare companies such as Hims & Hers and Ro.

Direct-to-consumer ARPU: $11.99 for US and Canada; $4.05 for other markets. Global D2C ARPU for the quarter increased by 1% YoY to $7.84 but was lower than last quarter鈥檚 $8.00. Overall financials: Total revenues declined 4% to $9.62 billion as theatrical revenues plunged 40%, and adjusted EBITDA for Warner Bros. Discovery鈥檚 entire business dropped 19% to $2.41 billion.

TikTok still has its place, Baus said, but requires a lot of content to achieve a few viral hits, and TikTok Shop is best suited for D2C brands and those that are already investing in product-focused content on the platform, such as beauty brands. On March 8, Reddit launched a new suite of tools to help marketers understand trending topics.

Two Big Pharma companies, Eli Lilly and Pfizer, rolled out direct-to-consumer (D2C) websites earlier this year in which patients connect with telehealth providers who can prescribe the manufacturer鈥檚 drugs. The benefits for each side:. For the drugmaker: Eliminating some of the middlemen in the pharmaceutical supply chain allows pharma companies to get their products to patients faster.

A tough spot: Nike鈥檚 revenue slide illustrates the scale of the company鈥檚 problems as it struggles to win back market share it lost to competitors like adidas, Hoka, and On Running during its shift to direct-to-consumer (D2C) sales.

Embracing mobile gives consumers access to a branded experience both online and in-store, while in-store technologies bring the digital world into the physical. To cater to shoppers no matter where or how they shop, brands should also make sure they鈥檙e balancing in-store and online rewards as well as D2C and wholesale commerce.

The boom times for ecommerce and retail have largely passed. 鈥淚t鈥檚 going to be harder [for retailers] to identify pockets of growth and opportunity. But, the good news is that it鈥檚 not going to be that roller coaster of demand fluctuations that has been challenging for retailers to navigate over the last couple of years,鈥� our analyst Blake Droesch said.

Health AI could have a similar engagement boost with Amazon鈥檚 health products and services as Amazon鈥檚 retail shopping assistant Rufus, which answered 274 million daily questions in October, per eComtent.

Kennedy Jr. to ban pharma direct-to-consumer advertising. A pharma ad deduction ban also could generate new revenues for the cost-cutting administration. Banning advertising tax deductions for pharma could generate $1.5 billion to $1.7 billion in federal tax revenues, according to Campaign for Sustainable Rx Pricing鈥檚 ad spending analysis of 10 leading pharma companies.